Revitalize Hydration for Feline CKD: Prevention & Support

Key Ingredients: Potassium and Citrate

Potassium and citrate play pivotal roles in maintaining overall health and are often deficient in pets’ diets. While potassium regulates fluid balance and aids in nerve and muscle function, citrate, a tricarboxylic acid trianion, is essential for plasma homeostasis and cellular energy metabolism. However, it’s often neglected despite its critical importance.[1,3,9]

Citrate, in particular, serves as a potent inhibitor in preventing calcium oxalate kidney stones, making it indispensable for urinary tract health. Its ability to maintain a healthy urine pH and act as an antimicrobial agent further underscores its significance in preventing urinary tract infections (UTIs) and related complications, such as CKD.[3,4,5]

Balancing Electrolytes and Preventing Complications

Revitalize Hydration’s precise dilution, when added to distilled water, creates a solution that enhances blood flow, prevents clotting, and naturally thins the blood. Moreover, it helps in balancing and reducing excess calcium and phosphate levels, addressing common issues associated with chronic kidney disease (CKD) in pets.

Potassium imbalances are prevalent in CKD cats, with low potassium levels occurring in approximately 30% of cases. Revitalize Hydration provides a convenient oral supplement to address these deficiencies effectively. Additionally, it aids in preventing hypokalemia and hypocitraturia, thereby reducing the risk of kidney stones, UTIs, and CKD progression.[2,5,8,16]

Mitigating Excess Phosphate and CKD Complications

Excess phosphate, often found in pet food, is linked to CKD and related complications. By reducing phosphate levels and promoting urinary pH regulation, Revitalize Hydration mitigates the risk of calcified arteries, kidney stones, and other CKD-associated issues.

Citrate emerges as the unsung hero in this battle against excess phosphate. By competing with phosphate for absorption into the plasma serum and raising pH levels, citrate facilitates calcium binding to bones, potentially averting CKD and bone disorders.[1,6-9,15] It’s important to emphasize the previous statement, as phosphate does the opposite, it pulls calcium from the bones into the plasma serum, which may be lead to all the adverse health issues listed above.

Conclusion: A Natural Approach to Pet Wellness

In conclusion, Bloom Bioscience’s Revitalize Hydration offers a Natural approach to pet wellness by addressing key physiological imbalances and preventing a myriad of health issues. From maintaining urinary tract health to mitigating CKD complications, its potent blend of ingredients provides robust support for pets’ overall well-being.

By incorporating Revitalize Hydration into your pet’s daily routine, you’re not just providing hydration but also proactively safeguarding against urinary tract infections, kidney stones, and other debilitating conditions. It’s a simple yet powerful step towards ensuring a long and healthy life for your beloved furry companions. Read more: the referenced Case Studies [11,12,13]

References:

1. Costello LC, Franklin RB. Plasma Citrate Homeostasis: How It Is Regulated; And Its Physiological and Clinical Implications. An Important, But Neglected, Relationship in Medicine. HSOA J Hum Endocrinol. 2016;1(1):005.
2. Strohmaier WL, Seilnacht J, Schubert G. Urinary stone formers with hypocitraturia and ‘normal’ urinary pH are at high risk for recurrence. Urol Int. 2012;88(3):294-7.
3. Williams NC, O’Neill LAJ. A Role for the Krebs Cycle Intermediate Citrate in Metabolic Reprogramming in Innate Immunity and Inflammation. Front Immunol. 2018 Feb 5;9:141.
4. Leslie SW, Bashir K. Hypocitraturia and Renal Calculi. StatPearls. 2023 May 30.
5. Dorsch R, Teichmann-Knorrn S, Sjetne Lund H. Urinary tract infection and subclinical bacteriuria in cats: A clinical update. J Feline Med Surg. 2019 Nov;21(11):1023-1038.
6. Granchi D, Torreggiani E, Massa A, Caudarella R, Di Pompo G, Baldini N. Potassium citrate prevents increased osteoclastogenesis resulting from acidic conditions: Implication for the treatment of postmenopausal bone loss. PLoS One. 2017 Jul 17;12(7):e0181230.
7. Granchi D, Baldini N, Ulivieri FM, Caudarella R. Role of Citrate in Pathophysiology and Medical Management of Bone Diseases. Nutrients. 2019 Oct 25;11(11):2576.
8. Humalda JK, et al. Effects of Potassium or Sodium Supplementation on Mineral Homeostasis: A Controlled Dietary Intervention Study. J Clin Endocrinol Metab. 2020 Sep 1;105(9):e3246–56.
9. Lin WS, Wang PY. Janus-faced citrate in aging and metabolism. Aging (Albany NY). 2022 Jun 17;14(12):4929-4930.
10. Perinpam M, Ware EB, Smith JA, Turner ST, Kardia SLR, Lieske JC. Association of urinary citrate excretion, pH, and net gastrointestinal alkali absorption with diet, diuretic use, and blood glucose concentration. Physiol Rep. 2017 Oct;5(19):e13411. doi: 10.14814/phy2.13411. Epub 2017 Oct 16. PMID: 29038354; PMCID: PMC5641929.
11. Efficacy of Revitalize Hydration supplementation (bloombioscience.com)
12. Management of Proteinuria and Elevated Liver Enzymes (bloombioscience.com)
13. A Proactive Strategy for Hematuria (bloombioscience.com)
14. Ruospo M, Palmer SC, Natale P, Craig JC, Vecchio M, Elder GJ, Strippoli GF. Phosphate binders for preventing and treating chronic kidney disease-mineral and bone disorder (CKD-MBD). Cochrane Database Syst Rev. 2018 Aug 22;8(8):CD006023. doi: 10.1002/14651858.CD006023.pub3. PMID: 30132304; PMCID: PMC6513594.
15. Bargagli M, Arena M, Naticchia A, Gambaro G, Mazzaferro S, Fuster D, Ferraro PM. The Role of Diet in Bone and Mineral Metabolism and Secondary Hyperparathyroidism. Nutrients. 2021 Jul 7;13(7):2328. doi: 10.3390/nu13072328. PMID: 34371838; PMCID: PMC8308808.
16. Stephen W. Leslie; Khalid Bashir Hypocitraturia and Renal Calculi. Update: May 30, 2023